Low vitamin C concentrations were associated with higher BMI and higher waist-to-height ratio.
There is an inverse relationship between vitamin C and BMI and waist circumference in adults.
Lower vitamin C concentrations were found to be associated with higher leptin concentrations. It has been observed that vitamin C dose-dependently inhibits leptin secretion in primary rat adipocytes.
Vitamin C supplementation reduces the gene expression of apelin, an adipokine associated with insulin resistance, obesity and increased inflammation in animal models.
Higher concentrations of apelin are related to high concentrations of leptin and proinflammatory cytokines.
Vitamin C has been shown to modify the response from rat adipocytes to high glucose levels, and to modulate the interaction between adipocytes and macrophages, protecting the adipocyte from a high glucose environment and from the inflammatory response associated with obesity.